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Similarly, data from human studies that assessed the contribution of folate deficiency or folate supplementation on cancer risk or progression is inconsistent and varies significantly based on factors such as folate dose, mode of intake (dietary versus supplementary), stage of development during exposure (prenatal versus postnatal), and the pathological status (normal versus neoplastic) of tissues [121,122,123,124]

This conversion process allows for a steady increase in plasma arginine levels, which ultimately leads to higher nitric oxide production

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Reported that the protective effect of tanshinone IIA against streptozotocin (STZ)-induced DKD may be related to the reduction of endoplasmic reticulum stress by attenuating PERK signaling activity