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The A-scan ultrasound showed high internal reflectivity, which is also atypical for a melanoma, although it is sometimes seen in a nevus or metastatic lesion

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This series of chain reactionsfrom endocrine disturbance (hyperandrogenism) to cellular events (granulosa cell senescence), to microenvironmental alteration (SASP-induced inflammation) and metabolic interaction (AGERAGE axis)collectively constitutes the pathological basis for the premature decline of ovarian function in patients with PCOS

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