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While we are still a long way away from pinpointing an analogous pathogenic species in MS, once identified, a specific immunotherapy targeting the relevant misfolded proteins, rather than downstream immune effectors as is the current approach, could be more effective in the progressive stages of MS

Clinical Response Evaluation Timeline How well patients respond to vitamin B12 therapy can differ

Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL

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The subcutaneous route allows for gradual absorption and distribution, which may help moderate peak concentrations and reduce acute toxicity compared to intravenous administration