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FIGURE 1 Activators of KCNQ Potassium Channels Depress Inspiratory Rhythmic Activity in vitro , Mimicking the Respiratory Effect of DAMGO KCNQ (Kv7) potassium channels are highly conserved voltage-gated potassium channels characterized by partial activation at subthreshold membrane potentials, exceptionally slow gating kinetics, and promiscuous coupling to diverse GPCRs (Brown and Adams, 1980