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This article explores the causes of dark stool

The high expression of MFI2 in melanoma cells (including the SK-MEL 28 cell line used in our study, which exhibits some of the highest MFI2 levels described to date [34]) may reflect an adaptation that provides proliferative advantages under the specific metabolic demands and microenvironmental conditions of tumors
Although inflammation may confound this association, CRP itself has been hypothesized to possess both pro-atherosclerotic and pro-inflammatory properties