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Other, newer drugs, such as SGLT2 inhibitors and GLP-1 receptor agonists are now also favored as first-line therapies in some cases, particularly for people who have cardiovascular and/or kidney health concerns in addition to diabetes

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Development of improved GPX4 inhibitors, including those with therapeutic potential, requires the identification of new electrophilic chemotypes and mechanisms of action that do not suffer these shortcomings

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