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Administration of pure ergothioneine to healthy human subjects: uptake, metabolism, and effects on biomarkers of oxidative damage and inflammation

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Dual targeting to overcome current challenges in multiple myeloma CAR T-cell treatment

Gross et al., 2014

Results We used the GSH/GSSG-Glo Assay to monitor GSH and GSSG levels and observe the oxidative stress in adherent HEK-293 cells and suspension K-562 cells dosed with menadione (Figures 3 and 4)

Conventional treatment options such as salicylates, corticosteroids, and immunosuppressants often come with severe side effects, limited bioavailability, and the development of drug resistance, which hampers their therapeutic effectiveness