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CYFIP1 belongs to the 4E-BPs family and in neurons, mainly at synapses, the FMRP-CYFIP1-eIF4E inhibitory complex regulates protein synthesis during synaptic activity, playing a pivotal role in the modulation of long-term synaptic plasticity at synapses (45, 46)

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SURMOUNT-1 (Jastreboff et al., NEJM 2022) reported 22.5% body weight loss at 72 weeks at the 15 mg dose

GD2, disialoganglioside, B7H3, B7 homolog 3

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