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Footnotes Edited by: Jing Gao, National Engineering Research Center for Oil Tea, China Reviewed by: Cheng-Ting Zi, Yunnan Agricultural University, China Maria Velez, Centro de Investigacin y Extensin Forestal Andino Patagnico (CIEFAP), Argentina Author contributions SL: Formal analysis, Investigation, Writing original draft

KGaA), 271353

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Bar Harbour, ME, USA)

Moreover, a number of molecular and cellular pathways related to hearing are conserved across species (10)

In detail, ROS are involved in disturbing antioxidant defenses, the mitochondria, microtubule, ion channels, and biomolecular functions, as well as inducing neuroinflammation, demyelination, and neuronal apoptosis in the process of PIPN ( Pt-induced ROS production easily breaks the balance of endogenous ROS and cellular antioxidant systems to trigger oxidative stress and mitochondrial dysfunction, resulting in the damage or loss of DRG cells containing abundant ROS-sensitive phospholipids (Khasabova et al., 2019)