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Senescent T cells in age-related diseases

This form has shown particular promise for intracellular delivery, meaning it can actually enter liver cells and provide protection where it is most needed

Emerging approaches advocate for a paradigm shift, integrating multimodal biomarkers, such as neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau protein (Tau), with in vivo imaging (fMRI, and PET), AI-driven patient stratification and adaptive trial designs

Det er biologisk og mekanistisk grunn til forvente at effektene observert i dyremodeller oversetter til mennesker, men dette er ikke formelt bevist

Ferroptosis is a form of programmed cell death regulated by multiple cellular metabolic pathways, such as iron metabolism, redox homeostasis, and mitochondrial activity, and executed by phospholipid hydroperoxides (PLOOHs), a form of lipid-based reactive oxygen species (ROS)[1, 2, 13]

All quantified proteins with non-missing values were included in the ranking