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[3] Hyperpigmentation in B12 deficiency occurs as a result of (1) decreased levels of reduced glutathione which activates tyrosinase and results in increased melanin synthesis, (2) defect in transfer of melanin from melanocytes to keratinocytes resulting in pigment incontinence, (3) increased biopterin in B12 deficiency increases hydroxylated phenylalanine which results in hyperpigmentation

In March 2025 it will be a year since the Nice Guideline on B12 Deficiency in over 16s was published

Everyone's different

These variations require specific dosing adjustments and helper nutrient combinations that can make the difference between treatment success and failure

A typical initial course might involve one 3ml ampoule administered intramuscularly once daily or 2-3 times per week for several weeks, followed by a maintenance dose if necessary, based on individual response and clinical need

Some patients explore peptide therapy for wellness goals related to recovery, energy, and healthy aging support