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Previous studies have shown that the absence of C-tail phosphorylation increases the flexibility of the linker between the SH3 and SH2 domains, known as an inducible snap lock, that may further enable the SH3 domain to accommodate not only extended polyproline sequences but also structurally diverse interaction partners 23

[DOI] [PMC free article] [PubMed] [Google Scholar] 290.Semwal R., Joshi S.K., Semwal R.B., Semwal D.K

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