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The model has profoundly advanced the conceptual disease paradigm by positing that RGCs degeneration in glaucoma involves parallel effects of pressure on molecularly distinct local self-destruct programs in dendrites, somata and axons

The specialized delivery of autocoids to an infectious site can therefore breakdown during severe infections and supports the use of COX-1 NSAIDs during severe traumas and infections, while chronic diseases require more refined therapies

The primary limitation remains the lack of published human clinical trials

People are dying from a 100-year-old drug

Signal Transduct Target Ther2021 Apr 16;6(1):152