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10.1056/NEJMra1505557 4
doi: 10.3389/fimmu.2022.1004885/full 31 NingZLiuYGuoDLinWJTangY
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Normally, monocytes are present in the blood, bone marrow, and spleen
However, oxidative stress or GSH depletion causes TXNIP to dissociate from TXN and instead bind to NLRP3, inducing conformational activation and promoting inflammasome assembly 53,54
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