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These experiments indicated that, in addition to requiring Cys-dependent de novo biosynthesis of GSH for survival (see above), TrxR1/Gsr-null livers require de novo biosynthesis of Cys via transsulfuration, and that they cannot effectively utilize cystine as a hepatic Cys source [107]

Bakaloudi DR, Halloran A, Rippin HL, et al

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Cao DL, Ye DW, Dai B, Zhang HL, Shen YJ, Zhu Y (2015) Association of glutathione S-transferase T1 and M1 polymorphisms with prostate cancer susceptibility in populations of Asian descent: a meta-analysis

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