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The solution should become clear

10.1016/j.addr.2018.08.007 Adv

In addition, studies indicate a reduction in oxidative stress markers within affected tissues

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This suggests the presence of an underlying hard-wired circuit, such that large populations of enteric neurons can be synaptically activated at the same time (Fig.5)
These include tendon and ligament damage, nerve damage, muscle tears, and sprains
