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Keywords: systemic lupus erythematosus, primary Sjgrens syndrome, secondary Sjgrens syndrome, polyautoimmunity, anti-Ro, anti-SSA, autoantibodies, pathogenesis Introduction Systemic lupus erythematosus (SLE) is a complex disorder of autoimmune background, multifactorial etiology, impairment of several organic systems resulting in a widespread spectrum of clinical manifestations, as well as variable prognosis and evolving clinical course characterized by the occurrence of episodes of active disease and remission