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Tables 1 and 2 summarize passive membrane diffusion and active transport membrane permeability, respectively, for select small molecule NNMT inhibitors for which structure activity relationships had been previously developed.[17] 1-MNA, a product inhibitor of NNMT[12, 24, 25] exhibited no passive permeability (Table 1)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 299.Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, et al

Alpha-MSH has been studied for anti-inflammatory effects across multiple inflammatory models, but the full parent molecule can also interact with melanocortin receptors involved in pigmentation and other biological effects