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Description
it is FDA approved and tends to be considered safe for most patients
Drug Metab Dispos 35:14551458

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In this syndrome, the lack of lipoic acid, due to the defective activity of lipoic synthase, causes the subsequent impairment in lipoid acid-dependent enzymes, such as PDH and KDH [126]

Nano-bio interactions: The presence of a multitude of proteins in the blood can bind tenaciously to the surface of nanoparticles, forming a protein crown, which alters their physicochemical characteristics and stability, thereby impeding the specific binding of target molecules to receptors (Ito et al., 1999)
