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This study also confirmed the wound-healing ability of graphene oxide (GO)/metformin (Met) hydrogels in vivo, indicating their wound healing-promoting effect in diabetic wounds [154]

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O primeiro medicamento peptdico a insulina foi isolado em 1921 e est comercialmente disponvel desde 1923

MATERIALS AND METHODS Animals Experiments were carried out on male 30050 g Charles River Wistar rats received from the breeding colony of Semmelweis University