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In short: in vitro, mechanistic certainty is high, in animals it is supportive but variable, in humans, preliminary / heterogeneous [63]

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We also found that two drugs affecting MRP1, MK-2206 which inhibits PI3K/AKT and therefore activation of MRP1 and MK-571 which blocks active MRP1, both inhibited EV release from BzATP-stimulated NLCs (Fig