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A recent multicenter cohort study comparing the efficacy and safety of ofatumumab plus methylprednisolone with methylprednisolone plus azathioprine in 16 and 22 patients with pemphigus, respectively, revealed that the ofatumumab group showed faster disease control, with 94% of ofatumumab patients achieving complete remission compared with 14% in the conventional group at 36 weeks [36]

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4.5 Gutkidney axis regulation The gutkidney axis refers to the bidirectional interaction between the intestinal microbiota and the kidneys, which plays an increasingly recognized role in CKD progression (43, 44)