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Description
Many of the alterations in enhancer methylation lies in the genes regulating the expression of cell cycle regulatory proteins like cyclin-dependent kinases (CDKs)
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For this gene, the transition from cytosine to thymine at position 677 has been reported to decrease the transcription level by 70% in the homozygous and by 40% in the heterozygous case, and both situations were associated with global DNA hypomethylation [60]
U S A 104, 24542459
Eijk et al
How oxidized low-density lipoprotein activates inflammatory responses
