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YZ and MW revised the manuscript
There is a continuous leakage of electrons from the electron transport chain (ETC), which is major source of ROS production
i Naringenin and Blumeatin
10: Gobburu JV, Agers H, Jusko WJ, Ynddal L
In addition, there is a hybrid receptor with components of the IR (one and one -chain) and the IGF-1R (one and one -chain), to which both insulin and IGF-1 can bind to, but with less affinity than that of their putative receptors [98100]
When these pathways are activated together, they create a coordinated signal that encourages stronger natural growth hormone pulses
