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siRNA, small interfering RNA

The L-arginine-nitric oxide pathway

Nature 465 , 793797 (2010)

In experimentally induced septic shock in rats, prostacyclin (iloprost) and nitric oxide prevented the sepsis-induced loss of red blood cell deformability via a complex mechanism [230]

This approach aims to maximize the potential benefits of MTH1 inhibition while mitigating any limitations observed in certain cancer types or with specific inhibitors

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