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doi:10.2174/1381612826666200523175806

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In this review, we first introduce metabolic pathways that enable glutamine to respond to diverse cellular needs and then discuss the metabolic link by which glutamine-derived metabolites may affect cellular metabolic processes, including NEAA synthesis, epigenetic modifications, and hypoxia adaptation

Furthermore, it has been reported that opioids treatment induces gene expression alteration of several proteins such as neurotransmitters, mediators, and transcription factors, known to be involved in the long-term molecular and cellular adaptation occurring during tolerance and dependence [39]

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It is not known to be toxic and does not interact negatively with other medications