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115,517 Indeed, even though human intelligence remains high long after 5 th decade of life, other systems show substantial decline in the physical capacities of youth

All enzymes that use O 2 in vivo are metalloenzymes and, in fact, even the oxygen transport proteins, hemoglobin and myoglobin, contain iron in the form of heme ( Chapter 5 )

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For example, after coated with a silica layer, the zinc dioxide (ZnO) NPs exhibited less cytotoxicity in human dermal fibroblast cells with less enzyme leakage, ROS production, and oxidative stress than their bare NPs, as a result of the surface modification restricting formation of free radicals and the release rate of zinc ions, as well as reducing the surface interactions of ZnO NPs with cells (Ramasamy et al., 2014)

Sustainability 13, 12336

The estimated enrollment is 313 patients