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doi: 10.1038/s41419-018-0331-5

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Expression of iron-related proteins at the neurovascular unit supports reduction and reoxidation of iron for transport through the blood-brain barrier

The Harding lab animal studies used various doses, often extrapolated by community members using simple body weight scaling

Hillare et al

An RCT in 36 patients with type 2 diabetes found that NAC (1,200 mg/day for 4 weeks) combined with a standard diabetes diet significantly reduced fasting glucose, HbA1c, and markers of oxidative stress compared to diet alone (Shahidi et al., J Diabetes Metab Disord, 2020) [56]