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Therefore, the adverse effects of caffeine observed in stored RBC units are potentially also direct, mediated both through disrupted purinergic signaling (ADORA2b) and direct enzymatic inhibition (G6PD), in part mimicking the increased susceptibility to hemolysis and impaired post-transfusion survival of RBC from G6PD-deficient donors
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Animal health condition was checked daily and body weight was measured at least twice weekly
The Val68Met variant leads to decreased intracellular trafficking and activity-dependent BDNF release and function 18
