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Description
The addition of PI3K inhibitors, including, MK2206, LY294002, IC87114, idelalisib, and TGR-1202, during expansion has been shown to maintain CAR T cells in a less differentiated state leading to increased downstream anti-tumor efficacy and persistence of CAR T cells in vivo (105, 121, 158)
Solid cancers
Supplementary information The online version contains supplementary material available at 10.1038/s41467-024-45808-9
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