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Y., Horvath, L

In CKD, reduced renal function limits TMAO clearance, whereas excessive levels in metabolic syndrome increase the risk of T2D and cardiovascular diseases
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Inhibition of QS appears to be the main mechanism of action for many natural phytochemicals, as they prevent the accumulation of QS signal molecules within biofilms, thereby downregulating the expression of virulence factors, and attenuating the immune response of the organism

doi:10.1056/NEJMoa1315815
For this hormonal signal to induce an enhanced polyQ aggregation on muscle cells and neurons, it requires functioning arylsulfatases SUL2 and SUL3 (Fig 3C)
