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45 demonstrated a seasonal effect in sheep with better oocyte quality results in spring than in autumn, although this study was carried out in prepubertal animals, where the endocrine profile is quite different from that of adults 46

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The compound is typically added to experimental systems to observe how reduced NNMT activity alters cellular behavior over time

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In particular, USP22 raised GSH content and reduced the occurrence of ferroptosis in cardiomyocytes by activating the Sirt1-p53/SLC7A11 axis [252]
