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These complexities highlight the need for a nuanced understanding of the role of signal 3 and cytokines on CD8 + T cells to optimize immunotherapeutic strategies and overcome resistance mechanisms

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10.1056/NEJM199105163242001 [DOI] [PubMed] [Google Scholar] Sinor JD, Du S, Venneti S, Blitzblau RC, Leszkiewicz DN, Rosenberg PA, & Aizenman E (2000)

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