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Adults received either placebo or EMP+ (Vit A 5760IU, Vit C 600 mg, Vit D 1440 IU, Vit E 360 IU, B1 18 mg, B2 13.5 mg, B3 90 mg,B5 21.6 mg, B6 36 mg, B9 1440 g, B12 900 g, Biotin 1080 g, Pantothenic acid21.6 mg, Ca 1320 mg, Fe 13.74 mg, P 840mg, I 204 g, Mg 600 mg, Zn 48 mg, Se204 g, Cu 7.2 mg, Mn 9.6 mg, Cr 624 g, Mo 144 g, K 240 mg, Germaniumsesquioxide 20.7 mg, B 2400 g, V 1194 g, Ni 29.4 g, Choline bitartrate 540mg, DL-phenylalanine 360 mg, Citrus bioflavonoids 240 mg, Inositol 180 mg,Glutamine 180 mg, L-methionine 60 mg, Gingko biloba 36 mg, grape seed extract45 mg)

The expression of chemokines and their receptors, (e.g., CX3CL1/CX3CR1, CCL2/CCR2, CXCL1/CXCR2, CXCL12/CXCR4 and CCL3/CCR5) is altered in CIPN [114, 115]

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We also benefited from the ABCD Classification system developed by the Australian Institute of Sport (AIS), which ranks sports foods and supplement ingredients into four groups according to scientific evidence and other practical considerations that determine whether a product is safe, permitted, and effective in improving sports performance [11], as well as the information provided by the organizations of thirdparty certification and testing of dietary and/or food supplements