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Kabuki syndrome type 1, ICF syndrome type 1, and Rubinstein-Taybi syndrome patients present with a wide spectrum of infections, and sepsis was the most common among ICF syndrome type 1 (19% of cases) ( Figure 4 )

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In addition, hypertension may disrupt connections in the temporal lobe, thalamus, and prefrontal cortex, especially in the hippocampus, leading to cognitive decline (Lee et al., Many studies have shown that hypertension is associated with WMHs (Haring, Additionally, hypertension is closely related to CMBs

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