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We are conscious of the limitations of the animal models [123], however in a clinical trial undertaken by this group to asses IGF-1 in liver function under cirrhosis with these same dosage (20 g/kg/day) no side effects were reported and liver function greatly increased [108]

Deficiency can occur in certain populations, including older adults, vegans, individuals with pernicious anaemia, those with malabsorption disorders such as Crohn's disease or coeliac disease, people who have had bariatric surgery or gastrectomy, and those on long-term medication such as metformin or acid-suppressing drugs

B12 is found in most animal derived foods, including meat, eggs, and dairy, with the highest bioavailable sources from liver

Documentation omits start and stop times

Breastfeeding must be discontinued during treatment and at least a week after the final dose

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