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Venography Venography was performed in rats with a suprahepatic occlusion of the inferior vena cava at 15 min post-ligation, using a C-VISION PLUS uoroscopy unit (Shimadzu, Japan)[18]

In some embodiments, the otic formulation or composition comprises between about 0.001% to about 3% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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1a, normal SD rats were placed in open field boxes to compare baseline and peptide-induced locomotor activities among the three treatment groups ( n = 68 animals per group)