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2020 May 19;12(5):1471
Why Cartilage Degenerates Several factors drive cartilage breakdown: Chronic Inflammation Inflammatory cytokines such as IL-1 and TNF- stimulate enzymes that degrade cartilage matrix
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Proteomic analysis showed that these significantly differentially expressed proteins are involved primarily in metabolic pathways including carbon metabolism, amino acid biosynthesis, pyruvate metabolism, glucagon signaling, pentose phosphate pathway, HIF-1 signaling and glycolysis/gluconeogenesis (Figure 4C)
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