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At our clinic in Doral, FL, PIH is one of the most frequent concerns we address in patients who have already completed acne treatment and are managing what the breakouts left behind

Nakao A

This is a known consideration in freeze-dried and frozen formulation research, where excipients such as mannitol are studied specifically to protect molecules through these phase changes, as covered in the Journal of Pharmaceutical Sciences review cited above

I think we need to be a bit skeptical

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