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This discrepancy may arise in part because the majority of B12 in serum is bound to the transport protein haptocorrin which is not physiologically active and thus unavailable for B12-dependent enzymatic reactions in cells (Green et al., 2017)

According to the NHS, addressing these types of nerve problems often requires a more rigorous approach

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While AOD-9604 is not FDA-approved as a prescription drug, it has received GRAS (Generally Recognized as Safe) status, indicating low toxicity and a good safety profile