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[2] Beyond adipose tissue, in vitro studies suggest AOD-9604 may engage cellular differentiation pathways in mesenchymal stem cells, chondrocytes, and myoblasts, indicating possible pleiotropic biological activity beyond its lipolytic mechanism

Another study reported both coenzyme Q 10 and vitamin E deficiencies among FRDA patients and suggested that co-supplementation with both compounds, at doses as low as 30 mg/day of coenzyme Q 10 and 4 IU/day of vitamin E, might improve disease symptoms (80)

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doi: 10.1074/jbc.M703091200

Secondary BAs, such as LCA and DCA, act as strong ligands for TGR5 and FXR, with their activation playing a role in immune regulation and anti-inflammatory functions [104]

These mutations were observed to decrease the ability of adrenocortical cells to effectively detoxify ROS