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335 As documented in this section and Table 3, antineoplastic agents/methods with ROS-inducing potential and their ROS-mediated antitumor mechanismscompiled from sources including the FDA database (www.fda.gov), ClinicalTrials.gov, and DrugBank ( diverse mechanisms of action ranging from metabolic interference to direct oxidative damage

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Based on a previous study, the following compounds have been found as GPx4 activator: lapatinib, ferrostatin, liproxstatin-1, and PKUMDL-LDL-102 (Fig