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Heme A1M'ed at the kidney in sickle cell disease

2023;97(6):e0050623

2.2 Regulatory pathways associated with the ABC transport protein family 2.2.1 PI3K/Akt pathway Phosphatidylinositol 3-kinase (PI3K) is an important lipid kinase involved in intracellular signaling and cascade reactions

J NEURO-ONCOL

The selectivity of IACS-16898 against the bromodomain of CBP and p300 was further evaluated using a DiscoverX BROMOscan assay, which showed high affinity for CBP and p300, demonstrating K d of 0.23 and 0.27 nM, respectively, and a higher than 300-fold (mostly higher than 1000-fold) selectivity against other bromodomains (Fig

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