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Description
Ronnekleiv O
Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) and induces the expression of over 500 cytoprotective genes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) 9,10,11 , thereby enhancing the cells resilience against more significant stressors

doi: 10.3390/ijms24076128

Importantly, Ebselen mimicked the activity of all selenium-dependent mammal GPXs and affected the redox state

Then, GSH swoops in to restore the enzyme, getting oxidized in the process

helps remove black/white heads