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Perspect Med Chem 1:2538 Lee AC, Crippen GM (2009) Predicting pKa

It has attracted significant scientific interest due to its apparent stability in harsh gastric environments and its role in tissue protection and repair-related research pathways

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Because heavy training often places stress on connective structures, compounds that interact with tissue signalling pathways attract significant interest

Regulatory context adds another layer

Current and Resolved Drug Shortages and Discontinuations Reported to FDA