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High blood pressure, atherogenic cholesterol particles, elevated blood sugar, smoking, chronic kidney disease, inflammation, inactivity, poor sleep, and genetic factors may accelerate vascular damage

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Stunkard AJ, Sorensen TIA, Hanis C, et al
~ AlphaMD Losing 41 pounds while building muscle sounds like the kind of transformation that would take a year of perfect adherence to diet and training, or maybe something only possible with unsustainable calorie restriction
