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Vitamin B12 deficiency that is allowed to progress for longer than three months may produce permanent degenerative lesions of the spinal cord

Thus, getting medical advice before starting any new health supplement is essential

Multiple sclerosis, in StatPearls treasure (Island, FL: StatPearls Publishing)

Clinical evidence supports B12's role in energy metabolism and neurologic function

15 March 2025 A Correction to this paper has been published: Abbreviations AMPK: AMP-activated protein kinase GHRH: Growth hormone releasing hormone CNS: Central nervous system GHRHR: GHRH-Receptor GH: Growth hormone GHR: Growth hormone receptor GHS-R1a: GH-secretagogue receptor 1a icv: Intracerebroventricular IGF-1: Insulin-like growth factor 1 IGFBP-3: Insulin-like growth factor binding protein 3 LEPR: Leptin receptor NPY: Neuropeptide Y OX-A: orexin-A cAMP-PKA: Cyclic AMP Protein Kinase A MAPK: Mitogen-activated protein kinase GPCR: G protein-coupled receptor SST: Somatostatin ARC: Arcuate Nucleus of the hypothalamus PeN: Periventricular Nucleus of the hypothalamus Pit-1: Pituitary transcription factor 1 PVH: Paraventricular hypothalamus of the hypothalamus ME: Median Eminence VMH: Ventromedial nucleus of the hypothalamus References Schally AV, Zhang X, Cai R, Hare JM, Granata R, Bartoli M