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Safety was consistent with the GLP-1 class, with GI adverse events as the predominant findings

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Importantly, menstrual cycle-related metabolic variability reflects not only estradiol and progesterone oscillations but also integrated adaptations across the hypothalamicpituitaryadrenal axis, autonomic nervous system, immune signaling, and gut microbiota

A continuous exposure might be necessary for chronic studies, whereas acute investigations might only require a single dose
