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FBS, DMEM, and tissue culture reagents were obtained from Invitrogen (Carlsbad, CA, USA)

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The role of TLR7 agonists in modulating COVID-19 severity in subjects with loss-of-function TLR7 variants

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found that secondary bile acids produced by gut microbes were associated with plasma levels of simvastatin and predicted the lipid-lowering effect of simvastatin, which may be an effect of the gut microbiota on the bioavailability of simvastatin

In addition, dysregulation of CPT1 has been implicated in the development of such metabolic disorders as obesity, metabolic-associated fatty liver disease (MAFLD), diabetic cardiomyopathy and the metabolic syndrome