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PD with RBD (RBD-PD) represents a clinically aggressive subtype characterized by more severe motor and nonmotor symptoms, prominent autonomic dysfunction, and accelerated disease progression
Surprisingly, we were unable to detect any specific change in the expression of other markers of oxidative stress, senescence or DNA damage/repair in the canities-affected melanocytes compared to surrounding bulbar keratinocytes

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Theories of depressive disorders include the monoaminergic, neurotrophic, glucocorticosteroid, glutaminergic, inflammatory, and cytokine theories

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